Will Vanilla Scrum Work for You?
Here is my take, borrowing a little language from the Lean/Kanban community... ask yourself, can your entire value stream be encapsulated within a single Scrum team? If there are steps in your process that happen either before your team starts, after your team starts, or you have dependencies on other teams during the development lifecycle, Vanilla Scrum probably isn't going to work.
Giving Vanilla Scrum a try without understanding your entire value stream, only results in the dev team being a local optimization in the larger enterprise. When I'm talking to clients that want to do Scrum, this is the first question I ask. If more than one team is at play... chances are I need more than Scrum to be successful.