Django is well-suited for e-commerce, and there are currently several nascent django e-commerce frameworks in development. This talk is about the development of django-oscar, a framework designed to leverage Django's core functionality to allow domain-driven e-commerce applications to be built. This is a very powerful approach.
Writing django apps which are flexible enough to be adapted to a wide variety of scenarios is a non-trivial problem which will be explored. The talk will also cover a range of e-commerce best practices and how they can be implemented in Django.
David's other presentation can be found here: Migrating from PHP to Python and Django