Mule ESB 3.8 by default supports only TLSV1.1 and TLSV1.2. Some applications need to post to endpoints that are based on TLSV1.0. In order for them to work locally while developing your application, you might have to enable TLSV1.0 in Anypoint Studio.

Follow the steps to enable TLSV1.0 so that your applications running through Anypoint Studio will not complain any errors:

1. Go to the AnyPoint Installation folder.
2. Navigate to Plugins directory if you are using Windows.
3. If you are using Mac, then navigate to Applications > Anypoint Studio > Contents > Eclipse > Plugins.
4. Now search for folder “org.mule.tooling.server.3.8.x.ee_6.1.x.yyy.mm.dd.” Navigate to directory “mule” and then to “conf” folder.
5. Now you should find files with the names “tls-default.conf” and “tls-fips140-2.conf.”
6. Edit each of the files by opening them and search for “enabledProtocols.”
7. You should see “enabledProtocols=TLSv1.1,TLSv1.2.”
8. Now add TLSv1 to the enabledProtocols.
9. It should look like “enabledProtocols=TLSv1,TLSv1.1,TLSv1.2.”

Now, restart your Anypoint Studio just to make sure that it picks up the new settings. Your apps should be supporting TLS1.0.

Similarly, if you need to disable TLSv1.0 (as it is not accepted by PCi compliance), remove it from the enabledProtocols.

Note: This feature of editing the TLS values is available since Studio 5.4.3 as per the MuleSoft website. I hope this helps!